The Predictive Value of Stress Shielding for Quantification of Adaptive Bone Resorption Around Hip Replacements
نویسندگان
چکیده
منابع مشابه
The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials.
Bone resorption around hip stems is a disturbing phenomenon, although its clinical significance and its eventual effects on replacement longevity are as yet uncertain. The relationship between implant flexibility and the extent of bone loss, frequently established in clinical patient series and animal experiments, does suggest that the changes in bone morphology are an effect of stress shieldin...
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15 صفحه اولDoxycycline inhibits bone resorption by human interface membrane cells from aseptically loose hip replacements.
Matrix metalloproteinases (MMPs) may have a role in the process of aseptic loosening. Doxycycline has been shown to inhibit MMPs. Our aim was to investigate the potential pharmacological effect of doxycycline on aseptic loosening. We used radiolabelled mouse calvariae cultured with human interface membrane cells from aseptically loosened hips. Bone resorption was confirmed in this model. The ef...
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ژورنال
عنوان ژورنال: Journal of Biomechanical Engineering
سال: 1997
ISSN: 0148-0731,1528-8951
DOI: 10.1115/1.2796084